Fois AG, Sotgiu E, Scano V, Negri S, Mellino S, Zinellu E, et al
n=118) *Values are Mean SD Type 1 Diabetes Pediatric (see Table 7) A randomized, 16-week, open-label, parallel design study of pediatric patients with type 1 diabetes (n=298) aged 4-18 years compared two subcutaneous infusion regimens administered via an external insulin pump: NOVOLOG (n=198) or insulin lispro (n=100)
Clinical data shows approximately 5 to 8 pounds of weight loss on Rybelsus 7mg and 14mg respectively, far less than the 30+ pounds average on injectable Wegovy
Phase 2 Obesity Trial Results (Jastreboff et al., 2023) The landmark Phase 2 trial enrolled 338 adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related comorbidity
Additionally, external factorsstress, sleep deprivation, and certain medicationscan amplify hunger signals and override the appetite-suppressing effects of GLP-1 therapy
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