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They monitor for improved sleep architecture (via wearable/tracking), morning recovery feeling, and reduction in stress hormones or improved hormone balance (if they have access to such measures)
This is also the structure Novo Nordisk's own investigational semaglutide+cagrilintide combination used in REDEFINE 1 (Garvey et al., NEJM 2025) both components stepped in parallel through a 16-week ramp rather than introduced together at maintenance
The quality here is paramount
These events may depolarize the GnRH neurons and modulate GnRH release
doi:10.1371/journal.pone.0180067 Boyle NB, Lawton C, Dye L
Thanks, Donald
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