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5 Caloric restriction, nutrient intake and dietary patterns: implications on longevity The study on longevity is far-reaching where various hallmarks of aging, genome instability, changes in epigenetic markers, loss of proteostasis, dysfunctional nutrient sensing, telomere attrition mitochondrial dysfunction, induction of cellular senescence, exhaustion of stem cell population and transformed intercellular communication are implicated [66, 76,77,78]

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