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Some people may find one area feels more comfortable, but thats usually down to technique, skin sensitivity, and tissue thickness rather than the area itself

Stimulation of erythrocyte ceramide formation by platelet-activating factor

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This discomfort can range from a mild, temporary ache to more pronounced soreness

J Clin Invest 117:21552163 Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K (2009) Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function