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301 , E1184E1190 (2011)
Garrido-Martin P, Nassar-Mansur MI, de la Llana-Ducros R, et al
This reaction is catalyzed by the enzyme glutathione reductase
Synthetic androgens increase cardiovascular event risk
Abbreviations ADC: Arginine decarboxylase ADI: Arginine deiminase ADI-PEG20: Pegylated arginine deiminase ALL: Acute lymphoblastic leukemia AML: Acute myeloid leukemia AOC: Aminooxetane-3-carboxylate ASL: Arginine-succinate lyase ASNS: Asparagine synthetase ASS1: Arginino-succinate synthetase ATP: Adenosine triphosphate BPTES: Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide BPTES-NP: BTPES nanoparticle B-Raf: v-raf murine sarcoma viral oncogene homolog B1 BRAFi: B-Raf inhibitor CQ: Chloroquine DFMO: D,L--difluoromethylornithine DNA: Deoxyribonucleic acid DON: 6-Diazo-5-oxo-L-norleucine E
The agency argues rejecting the request would "maximize patient safety" and adhere to Congress' intent to incentivize drug development while allowing compounding during temporary drug shortages
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