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Biomarker Context and Dosing Response Variability Dosing efficacy varies significantly across individuals due to differences in metabolic rate, insulin sensitivity, glucagon-like peptide-1 receptor expression, and gastrointestinal motility

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Univariate and multivariate analyses were performed using the KaplanMeier method or Cox proportional hazards regression

Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects

Many patients use GLP-1 injections for a set period before transitioning to maintenance support

So the clinical data gap is also a market strategy