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SUMOylation regulates the transcriptional activity of NRF2, affects its interaction with other proteins and intracellular localization, and protects NRF2 from ubiquitination-mediated degradation [129]
Pancreatic islet tissue disorder induced by fibrosis is another important mechanism of -cell failure [7, 31]
They can encapsulate a wide array of therapeutic agents, including natural compounds (e.g., Notoginsenoside R1), small molecule inhibitors, and gene therapies targeting oxidative stress pathways (Li H
Important: State trends are directional only
426 The activation of Ras is predominantly driven by ligand binding to receptor tyrosine kinases (RTKs) rather than GPCRs
