Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer
Ranucci, G., Di Dato, F., Spagnuolo, M., Vajro, P
Trong cuc sng hin i, thc khuya, cng thng ko di, nhim mi trng, ch n thiu cn i hay thng xuyn tip xc vi tia UV u c th lm gia tng stress oxy ha
USA 101 , 1592715932 (2004)
These are not diagnostic by themselves, but pattern recognition is powerful
Currently, several senolytics were reported to kill senescent cells ( In this study, we tested the hypothesis that FOXO4-DRI treatment can selectively remove senescent cells in expanded human chondrocytes, thus enhancing their potential to generate high-quality cartilage