An injectable TME-responsive nanocomposite hydrogel incorporating IL11R-targeted liposomes has also been developed for local delivery of cisplatin-loaded MnO2 along with a MYC inhibitor, enabling sustained drug release and reshaping of the immune microenvironment in MYC-amplified osteosarcoma (45)
The neuroprotective effects of targeting key factors of neuronal cell death in neurodegenerative diseases: the role of ER stress, oxidative stress, and neuroinflammation
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SOCS1 (suppressor of cytokine signaling 1) protein is a negative regulator of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway and has tumor suppressor activity
By binding to IGF-1R, IGF-1 can affect metabolism, cell growth (hypertrophy), differentiation and cell division (hyperplasia), prevention of cell death (apoptosis), normal development, and even malignant growth
Generative AI statement The author(s) declared that generative AI was used in the creation of this manuscript