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Their presence in the skin is thought to protect against the damaging effects of actinic irradiation
In the SURMOUNT-5 trial, fewer patients stopped tirzepatide due to gastrointestinal side effects (2.7%) compared to semaglutide (5.6%)
The numbers of patients who required retinal photocoagulation were 38 (2.3%) in the semaglutide group versus 20 (1.2%) in the placebo group, the numbers of those who required the use of an intravitreal agent were 16 (1.0%) versus 13 (0.8%), the numbers of those who had a vitreous hemorrhage were 16 (1.0%) versus 7 (0.4%), and the numbers of those who had an onset of diabetes-related blindness were 5 (0.3%) versus 1 (0.1%) (Table S9 in the Supplementary Appendix)
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