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Firstly, some people believe that cerebral insulin resistance in patients with AD may not be insulin resistance in the true sense of the word but may instead arise from dysfunctional insulin transport across the BBB and that this transport defect may be caused by abnormal BBB function indirectly resulting from peripheral insulin resistance (Qian et al., 2024)
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Slowed gastric emptying: They slow down the rate at which the stomach empties its contents into the small intestine, so you feel fuller for longer after eating
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However, vesicular storage relies entirely on a proton gradient generated by active, ATP-consuming V-ATPases in the vesicle membrane (Wimalasena, 2011)
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