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Semaglutide trials showed an average weight loss of approximately 15%, indicating that the medication alters baseline physiology but typically requires ongoing support to sustain results
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Journal of Obesity & Metabolic Syndrome
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The strengths of this meta-analysis are the inclusion of all GLP-1RA CVOTs published until June 2021, the very large number of participants, the use of MACE as the main endpoint, the high quality of all trials which minimizes the risk of bias, and the absence of heterogeneity for all the endpoints considered
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