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Confirmed ORR was 49.0% (95% CI, 39.0 to 59.1) and 56.0% (95% CI, 41.3 to 70.0) and median DoR was 16.8 (95% CI, 6.4 to not estimable) and NR (95% CI, 8.3 to NR) with 5.4 and 6.4 mg/kg, respectively [36]
Pires M, Rego AC (2023) Apoe4 and Alzheimers disease pathogenesismitochondrial deregulation and targeted therapeutic strategies
Katagiri, T., & Watabe, T
[11] [53] [54] [55] Evidence-based data from the literature are relatively limited, and some experts suggest that long-term phentermine pharmacotherapy for obesity does not induce abuse or psychological dependence (addiction), drug craving, and that abrupt treatment cessation within the normal prescription dose range does not induce amphetamine-like withdrawal
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This stability profile is one reason the fragment was selected for further mechanistic study after its identification in the parent gastric protein
