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1% acetic acid is an acceptable alternative

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327 A meta-analysis of 14 randomized controlled trials found that alosetron or cilansetron, another 5-HT3 antagonist, were more effective than placebo or mebeverine (an anti-spasmodic agent) for improving abdominal pain and discomfort and IBS symptoms overall in patients with non-constipated IBS or IBS-D