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However, these established mechanisms have significant limitations
10.1016/j.freeradbiomed.2020.10.002 Free Radic Biol Med
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It leads to the accumulation of modified, potentially toxic proteins in neurons and can cause neuronal injury or premature neuronal death by apoptosis or necrosis (Dasuri et al., 2013)
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Although we may not have sufficient power to detect significant changes in our secondary outcomes (tau PET, MRIs, CSF AD biomarkers and cognition), including a nine-month follow-up will help provide preliminary evidence of successful modification of disease trajectory over a one-year period
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