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In a Phase I study with recombinant human thymosin beta-4, the terminal half-life was about 0.5 to 2.08 hours, for example 1.02 hours at 0.5 microg/kg and up to 2.08 hours at 25 microg/kg, with linear, non-accumulating kinetics and dose-proportional Cmax Wang et al., 2021

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Those with the MTHFR genetic mutation, certain developmental delays in children, and other conditions linked to impaired methylation often find synthetic forms ineffective, making methylcobalamin injections vital

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Sikiri's group were so struck that they proposed it might be the first of an entirely new class of medicines "a useful prototype of a new class of drugs," which they called organoprotective agents [9]

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