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Intranasal administration of peptides has been shown effective due to the following factors [27]: Large surface area Permeable endothelial membrane Elimination of first-pass effect Good circulation Researchers who wish to administer the BPC-157 and TB-500 blend via a nasal spray are encouraged to take certain precautions to ensure delivery of maximum bioavailability: To optimize absorption: Wait up to one minute between sprays via the same nostril to prevent oversaturating the nasal membrane and thus losing peptide due to swallowing
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While a small portion can be converted into active B12, it may replace the bodys natural stores with inactive B12
PMID:29155147 Babula JJ, et al
Patients were to be randomized to 1200 mg, 450 mg, or placebo, administered intravenously daily for 3 days followed by weekly for 4 weeks
