Once reconstituted in bacteriostatic water, most manufacturers recommend refrigeration at 2 to 8 degrees Celsius and use within 28 days, because repeated freeze-thaw cycles and ambient warmth accelerate peptide bond hydrolysis and disulfide bond oxidation
Allergic reactions typically cause bilateral (both eyes) swelling that responds well to antihistamines and cool compresses, while infections usually affect one eye initially
It's not a chronic, chronic thing forever, but you get a couple of poor nights of sleep
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however, these outcomes remain confined to preclinical research and require further investigation in human studies