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Patients have reported a number of side effects, including nausea, vomiting, diarrhea, stomach pain, and constipation

Well-controlled glucose levels prevent osmotic diuresis

This is because hemoglobin A1C (a measure of blood sugar control) and sex hormone-binding globulin (SHBG) are inversely correlated: as A1C improves with weight loss, SHBG levels may rise, which can bind more testosterone and reduce the amount that circulates freely in the bloodstream

Journal of Applied Genetics, 54(4), 461472

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