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Chronic hyperglycaemia, the production of reactive oxygen species (ROS), and the release of inflammatory cytokines are some of the factors causing endothelial dysfunction in patients with diabetes [11, 12]
Just as nephrologists are adept at detecting and managing the hyperkalemia of renin-angiotensin-system (RAS) inhibitors, we will need to master the art of treating the gastrointestinal disorders that are found in over half the recipients of GLP-1s (Figure 9)
Calcitonin, for instance, has been shown to activate several subtypes of the amylin receptor (42)
