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Novel GLP-1 analog supaglutide reduces HFD-induced obesity associated with increased Ucp-1 in white adipose tissue in mice
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Six Phase I/II clinical trials enrolling approximately 900 participants confirmed an excellent safety profile with no serious adverse events attributed to the compound
A large number of bioactive molecules can be cleaved by DPP-4 in vitro , but only a few of these have been demonstrated to be physiological substrates
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