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When adding GLP-1-R-Antagonist Exendin (9-36), the effects of Liraglutide were reversed, indicating receptor-mediated action [13]

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These findings are significant as they indicate that semaglutide can alleviate the pressure overload on the RV and reduce pathological remodelling, which are key factors contributing to the progression of RV dysfunction [14]

Paraoxonase also has antioxidant properties, as it circulates in the bloodstream and is associated with HDL (good cholesterol)

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