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Materials and methods Animal experiments C57BL/6J aged (20 months) male mice and mast cell deficient c-Kit wsh /cKit wsh mice (12 months) were housed in a specific pathogen-free facility (light cycle 12/12 h light/dark)

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Nausea is the primary side effect during titration

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When fat volume decreases faster than the skin can contract, laxity becomes more visible, especially in the face, neck, arms, abdomen, and thighs