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Practical Considerations for Clinicians When adding GLP1s to a liver-focused treatment plan: Evaluate contraindications (e.g., history of medullary thyroid cancer) Educate patients about common side effects and gradual dose titration Use liver biomarkers and imaging to monitor response over time Ensure cost and access considerations are addressed up front For additional guidance, consult Healthcare.pro or professional society recommendations to stay current on metabolic liver disease management

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In line with that, a human study using the SS agonist pasireotide, with a high affinity for SSTR5, resulted in both decreased insulin and GLP-1 levels (53)