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It means there's limited formal evidence on safety, and caution is warranted

Five days later, the transcript levels of Pelo, Hbs1, E3, -actin, and -tubulin were tested with RT-qPCR assay, while the accumulation levels of Pelo, Hbs1, E3, P8, Pns11, -actin, and -tubulin were determined by western blot assay as described above

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Mechanism-Based Side-Effect Risk: How the Two Differ The biological origins of AOD-9604 and MOTS-c predict distinct side-effect profiles, even in the absence of direct comparison data

Nat Med (2019) 25:3588

Increasing adoption of GST-tagged recombinant proteins Researchers increasingly utilize GST-tagged proteins in molecular biology and drug discovery applications because they simplify purification and improve protein stability during analysis