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Similar results were obtained with mRNA expression of MMP-2 ( P =0.01), stromal-derived factor-1 (SDF-1) ( P =0.01), tumor growth factor (TGF)- ( P =0.001) and poly-(ADP-ribose) polymerase (PARP) that occurs in response to DNA damage ( P =0.001) (Figure 5b)

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Conversely, constipation has been shown to persist longer than other GI side effects and is more frequently observed in obesity-focused studies

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PubMed, Ivanov, Alexandre, et al