However, there are a few things to keep in mind: Zinc Levels: Some studies suggest that long-term, high-dose glutathione supplementation may affect zinc levels
mild warmth or slight fatigue may occur briefly
Those who want products with Glutathione that is quickly absorbed into the skin
FDA therefore says it lacks enough information to know whether such products would harm humans
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Glutathione may potentially interact with certain medications, particularly chemotherapy agents where glutathione's protective effects might theoretically affect treatment efficacy, nitroglycerin and other nitrates used for cardiovascular conditions, and immunosuppressive medications where glutathione's immune-supportive effects might theoretically reduce medication effectiveness