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This explains the lack of tolerance and dependence liability observed in animal studies

The concentration of cystine in blood is higher in women than in men and also increases with age

For many patients, the significant health benefits of sustained weight loss may outweigh mild to moderate musculoskeletal discomfort

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Pharmacodynamic Effects and Duration Despite measurable plasma clearance, pharmacodynamic effects extend well beyond plasma half-life[20]: Weight loss effects continue throughout treatment with no plateau observed within 48-week study periods Glycemic improvements persist between weekly doses with stable glucose control Appetite suppression effects remain consistent throughout dosing intervals Tissue receptor occupancy likely exceeds plasma peptide concentrations This disconnect between pharmacokinetics and pharmacodynamics suggests prolonged receptor engagement, tissue depot effects, or persistent downstream signaling cascade activation