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Liver Int 40(7):16551669
Obesity pathophysiology is multifactorial and involves social, psychological and behavioral factors, genetic and metabolic predisposition (5)
Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)
Gang Jiang
This delayed gastric emptyinga key mechanism for reducing appetitecan also delay absorption of oral medications, including antibiotics
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