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Similar to the responses that occur with other exposures, GSH is initially increased to very high levels in the ELF with CS exposure

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Moreover, p53 serves as a critical mediator to affect the activity of system XC- by downregulating SLC7A11 transcription and augmenting the expression of spermine/spermidine-n1-acetyltransferase 1, raising the level of ALOX15 and boosting the accumulation of cytoplasmic peroxides (Ou et al., 2016

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