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Normally, the kidney and liver rely heavily on oxidative phosphorylation for energy production as both the liver and the kidney are dense with mitochondria

doi: 10.1159/000485089 187 McNeilEMAstellKRRitchieA-MShaveSHoustonDRBakraniaPet al

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It was suggested that the MITOLHMOX2 axis may respond to and maintain mitochondrial iron homeostasis, so we next generated HMOX1 KO cells, HMOX2 KO cells and DKO cells to determine the effect of HMOX on mitochondrial iron levels (Fig