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A 2024 study in dexamethasone-induced NASH rats demonstrated that L-carnitine restored Akt phosphorylation, inhibited FOXO1 nuclear translocation, and downregulated autophagy and apoptosis markers (LC3, P62, caspase-3, p-MLKL) via the Akt/FOXO1 pathway (59)

Targeting p53 presents a substantial risk of off-target effects

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