For instance, semaglutide users face a relative risk of 2.10 for constipation compared to placebo, while tirzepatide users have an even higher relative risk of 3.36
The Lancet , 384(9945), 705-717
Both ingredients are active, both can cause initial irritation, and using them simultaneously may overwhelm sensitive skin
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Gastrointestinal issues (nausea, vomiting, constipation) can result from the use of both semaglutide and tirzepatide
Kulkarni SS, Watson EE et al (2019) Diselenideselenoester ligation for chemical protein synthesis