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If you're talking about blood sugar and fullness signals and all that, it makes sense that you're doing it with meals, although I could see why people might think doing it between meals could have its own positive effect of potentially reducing your hunger signals, for example
Bennett BJ, Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ: Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation
We can often avoid some of those side effects if we increase the dose slowly and not just increase the dose once a month
Potential Benefits: A Summary Based on the available (predominantly preclinical) literature, the following potential benefits have been identified: Risks & Safety Considerations Known & Reported Side Effects Because large-scale human trials are lacking, our understanding of the side effect profile is limited
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