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For instance, a 2017 review showed that taking L-carnitine for 3 days had no effect on markers of brain function including reaction time, vigilance, immediate memory, and delayed recall in young adults without cognitive impairment
APR-246 is a small molecule inhibitor which has received lot of attention for its ability to reactivate the transcriptional activity of p53 mutants in different cell types [55]
More serious side effects are rare but can occur
This is the main reason some patients discontinue
subsequent preclinical studies have thus screened agonists with primates with Trp33 ECD or receptor mutants with substitution of Ser33 ECD by Trp33 ECD
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