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Despite the cost and thanks to considerable coverage under US private insurance the drugs have spread like wildfire throughout the US, with an estimated one in every eight adults in the country having tried them
In addition, cotadutide was shown to be safe and, in common with the GLP-1 analogues, was associated with dose-dependent gastrointestinal adverse events, especially nausea and vomiting [82]
But as GLP-1 therapies continue to help patients achieve significant, life changing weight loss, another conversation is gaining attention and it deserves just as much care and expertise
Current guidelines suggest a target of 1.2 to 1.6 grams of protein per kilogram of body weight per day during active weight loss in adults
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