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Potential off-target effects: broad changes to methylation could, in theory, affect gene expression in ways not yet characterised

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however, in exposed groups, CRE-treated animals in groups 5 and 6 indicated slightly better toleration against radiation than those in group 4

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Main body: We present a structured, fertility-centered, hypothesis-generating narrative synthesis of the metabolicreproductivepregnancy continuum in PCOS, integrating evidence from randomized trials, observational studies, reviews, and clinical guidance