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Through the Na + /K + pump, astrocytes accumulate K + during periods of high neuronal activity and release it back to neurons when activity subsides
Activation of the GLP-1 receptor delays gastric emptying and reduces small-bowel and colonic transit via vagal and enteric neural pathways, which may precipitate ileus-like states or unmask subclinical obstruction
The activated Akt phosphorylates and inactivates Bad, a pro-apoptotic member of the bcl-2 family, therefore promoting cell survival (17)
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It presents diagnostic criteria that are not yet consolidated in the literature due to its variable morphological, immunohistochemical (IHC), and genetic pattern, which is not yet fully elucidated.2,3 Thus, this case demonstrates an evolution of NF1-related MPNST, the diagnostic difficulties, as well as the role of the dermatologist in the final diagnosis of the neoplasm
