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No, it is not recommended to skip the lower doses

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Clinical Studies 14.1 Overview of Clinical Studies SOLIQUA 100/33 was evaluated in two randomized clinical studies in patients with type 2 diabetes mellitus

A gap over 90 days between prescription fills marked the end of treatment, to account for immortal time bias [23]

When I tried to find a clear ceiling in the data, the honest answer is we do not have long-term data yet