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In the late stages of PD, the key molecular pathogenic mechanisms include the misfolding and aggregation of -synuclein, mitochondrial dysfunction, impaired protein clearance (related to inefficient ubiquitin-proteasome and autophagy-lysosomal systems), neuroinflammation and oxidative stress (57)
Glutathione depletion renders hepatocytes vulnerable to TNF-alpha-induced apoptosis, contributing to alcoholic hepatitis [6][35]
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2024 ESC guidelines for the management of atrial fibrillation developed in collaboration with the European association for Cardio-Thoracic surgery (EACTS)
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Fight the Battle Against Toxic Damage
"It's untested and unproven
