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Early diagnosis is considered as the key improvement index for the most desirable outcomes (i.e., reduced joint destruction, less radiologic progression, no functional disability, and disease modifying anti-rheumatic drugs (DMARD)-free remission) as well as cost-effectiveness as the first 12 weeks after early symptoms occur is regarded as the optimal therapeutic window

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Because of it's long duration of action (days to weeks), echothiophate provides round the clock control of intraocular pressure

A high B12 in someone who isn't taking B12 supplements is the version that most warrants a deeper look