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Advantage : Neither (tie) Weight Loss Efficacy# Orforglipron : ATTAIN-1 demonstrated 12.4% mean weight loss at 36 mg over 72 weeks (efficacy estimand)

129 Multiomics analyses have revealed metabolic shifts in retinal microglia, 130 including a bias for glycolysis and reduced tricarboxylic acid cycle activity in diabetic models

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A potential mechanism of receptor resensitization