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In addition, they found that ghrelin strengthened hippocampus-ventral striatum coupling during food conditioning (Han et al., 2018a)
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Hoshino, A
Based on these two signal pathways, insulin enhances PDA development through mediating metabolic reprogram, crosstalk with IGF-1, strengthening drug resistance, and stimulating tumor microenvironment (inflammation, fibrosis, and neo-angiogenesis) formation
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