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It requires regular INR monitoring (target 2.0 to 3.0 for AF), carries more drug-food interactions, and the ARISTOTLE trial demonstrated that it produces more major bleeds than apixaban

Industry analysts project a potential launch in 2028, though timelines could shift depending on regulatory review

They analyzed the plasma lactic acid levels of 10 participants for 7 days, and provided dosages of L-Carnitine throughout

This creates a situation where the therapeutic benefits of one medication may be partially offset by the adverse effects of the other