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While GLP-1 RA variants had "consistent cardiometabolic effects" across all groups, the researchers said the negative impacts on mental health were "more varied," concluding that any behavioral changes are "likely not acting directly through [the medications]." SEMAGLUTIDE FOUND TO HAVE SHOCKING BENEFIT FOR LIVER DISEASE PATIENTS IN NEW STUDY Doctors weigh in on medications and mood Dr

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Many metabolic improvements can also diminish after stopping the drug

For a deeper dive into what side effects often improve over time, see our semaglutide side effects long-term guide

These medications also impact levels of insulin and the hormone glucagon in the body