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Less Common Side Effects: In rare cases, Rybelsus can lead to more serious conditions such as: Allergic responses (such as hives, swelling, or breathing difficulties) Pancreatitis (inflammation of the pancreas) Gallbladder disease Kidney problems Liver problems Heightened risk of hypoglycemia (low blood sugar) in individuals using insulin or other diabetes medications Hair loss Skin rash Rybelsus may cause hypoglycemia, or low blood sugar, particularly when its used in combination with other diabetes medications like insulin

The typical elevation of 1-4 beats per minute falls within normal physiological variation and is comparable to the heart rate changes seen with routine daily activities

By the numbers: In Q1 2026, the pharma giant reported $19.8B in revenue, up 56% YoY, blowing past expectations while raising full-year guidance to $82B$85B