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Integrating the proteomic and metabolic datasets, we discovered that enzymes pivotal to cysteine biosynthesis, such as cystathionine beta-synthase (CBS) [27], and key glutathione biosynthesis genes, including glutamate-cysteine ligase catalytic subunit (GCLC) [28] and Glutamate-cysteine ligase regulatory subunit (GCLM) [29], were key downstream targets downregulated upon DDX3X inhibition (Fig

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This effect typically peaks during the first week of use and diminishes substantially by week two or three

Peptides are short chains of amino acids naturally occurring in the body that play many important roles 1 Peptide synthesis in vivo | Friedberg et al

The injection of methotrexate caused an increase in the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, cholesterol, triacylglycerides, and low-density lipoprotein-cholesterol, and a decrease in high-density lipoprotein-cholesterol (HDL-cholesterol)

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