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There has not been a UL (upper intake level) established for B12 because it is not stored in your body and therefore, can not build up enough to cause serious adverse side effects for most people
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Retrieved from Wharton, S., Rosenstock, J., Konige, M., et al
Competing interests The authors declare that there are no conflicts of interest
Clinicians should: Assess baseline HbA1c and current glycemic control before discontinuation Implement or intensify alternative therapies (metformin, SGLT2 inhibitors, or other agents) before or concurrent with tirzepatide cessation Increase home glucose monitoring frequency for several weeks post-discontinuation Schedule follow-up to evaluate metabolic stability Special consideration for insulin or sulfonylurea users : Patients taking these medications alongside tirzepatide may need proactive dose adjustments when stopping tirzepatide to prevent hypoglycemia
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