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Birsoy and colleagues also found how mitochondrial glutathione drives cancer spread: not by acting as an antioxidantan effect ruled out through multiple experimentsbut by signaling to activate ATF4, a transcription factor that helps cancer cells survive in low-oxygen conditions
While the cells of the hepatic parenchyma have the flexibility to adapt to changing physiological demands with reversible functional and morphological alterations, sufficient stress, or noxious stimuli may lead to inability to maintain homeostasis and adverse cellular adaptations
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