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Semaglutide targets GLP-1 pathways involved in appetite and metabolic regulation, while cagrilintide, a long-acting amylin analogue, enhances satiety through distinct central nervous system pathways

By inhibiting this interaction, FOXO4-DRI allows reactivation of the apoptotic pathway in non-proliferative senescent cells, leading to their selective elimination without damaging healthy tissue

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Weeks 5 through 8: 0.5 mg once weekly